GPC6 and osteoporosis: Especially, GPC6 may be associated with LDH by causing osteoporosis (Dequeker, 1997; Im & Kim, 2014) as well as play an important role in cartilage damage by WNT pathway, whose structures are a main part of the endplate (van den Bosch et al., 2015; Daly, Ghosh, Jenkin, Oehme, & Goldschlager, 2016).