AKT1 and metabolic disease: Williams et al found that DMY prevents plaque formation in the aortas of ApoE knockout mice fed with HFD.10 Liu et al found that DMY has cardioprotective effects via the PI3K/Akt signalling pathway.11 Luo et al reported that DMY protects HUVECs from oxidative damage by activating Akt.12 These results suggested that DMY could reduce atherosclerosis and suppressed the pathologically related metabolic disorders via the PI3K/Akt signalling pathway.