For example Resveratrol protects PC12 cells from oxidative damage induced by high glucose through activating PI3K/Akt/FoxO3a signalling pathway.14 Tsuchiya et al found that FoxO inhibition in endothelial cells to protect mice from atherosclerosis, Knockout of FoxO in mice revealed that increased oxidative stress and accelerates atherosclerosis.15, 16 The previous studies have shown that DMY play cardioprotective effects via the PI3K/Akt signalling pathway.11, 12 However, whether DMY can protect HUVECs against oxidative damage via the PI3K/Akt/FoxO3a signalling pathway remains unclear. The gene discussed is AKT1; the disease is atherosclerosis.