The previous studies have shown that hydrogen peroxide induces cardiomyocyte apoptosis by inhibiting the PI3K/Akt pathway.33 The PI3K/Akt pathway has shown related to the human atherosclerosis.34 FoxO3a is an important downstream target of the PI3K/Akt pathway, which was mainly regulated by Akt. The gene discussed is FOXO3; the disease is atherosclerosis.