TRPA1 and dermatitis: In multiple published studies of IMQ treatment as a model of PsD, 5 or more days of topical treatment with IMQ have been used as a standard endpoint for treatment.6, 16, 24, 26 Indeed, in our studies, we did not observe an obvious difference in skin inflammation parameters between WT and TRPA1 KO mice on day 3, suggesting that the role of TRPA1 may be later in the develop of psoriatic changes in this model.