In summary, our data indicate that Wnt3a, as a canonical ligand for the Wnt signalling pathway, binds to its receptor on the membrane of SCCHN cells, activates the canonical Wnt signalling pathway, accelerates the nuclear translocation of β‐catenin and then enhances the expression of Beclin1. This evidence concerns the gene WNT3A and head and neck squamous cell carcinoma.