WNT3A and head and neck squamous cell carcinoma: This study not only revealed the signalling interaction by which Wnt3a‐mediated activation of the canonical Wnt signalling pathway induces protective autophagy and contributes to SCCHN radioresistance, but also provides a clinical opportunity involving a combinational target of the Wnt signalling pathway and autophagy for treating patients with SCCHN with radioresistance.