In this disease setting, several groups have found an association of p16 expression with biochemical recurrence and/or PCa specific survival23, 25, 29 while other groups have not observed this association.25, 26 As discussed by Remo et al,25 this may be due in part to factors such as the IHC protocol, the scoring system, group choice for analysis and patient selection. Here, CDKN2A is linked to posterior cortical atrophy.