We did not observe any association of p16 staining in nuclei or cytoplasm of benign or cancer tissues with age, body mass index, preoperative PSA, Gleason score, extracapsular extension, seminal vesicle invasion, pelvic lymph node metastasis, biochemical recurrence, or death from PCa or other causes (Table S2). The gene discussed is CDKN2A; the disease is cancer.