This strong reduction in activity does not induce any disease symptoms associated with human TPI deficiency, including hemolytic anemia, neurological dysfunction, or shortened lifespan.4, 21, 27 As disease symptoms amplify in humans with age, we also investigated 2‐year old mice, but could not detect any notable phenotypes at this age either. This evidence concerns the gene TPI1 and hyperinsulinemic hypoglycemia, familial, 4.