KLK3 and neoplasm: PIVOT investigators reported all-cause and disease-specific mortalities and bone metastases at 4, 8 and 12 years follow-up according to race (white, black or other), age (65<years≥65), Gleason score (<7≥), PSA level (≤10>), risk of tumor (low, intermediate and high), Charlson index score (0 vs. ≥1) and self-report performance status (0 vs. 1–4) (27).