In the darkgray module, we found five hub genes positively correlated with maternal BMI and negatively correlated with low birth weight: XLOC_000346, AHSP, XLOC_013489, SLC4A1, and HBQ1. The hub genes in the darkred module (FZD4, CDC42EP2, COL15A1, TBXA2R, EHD2, GPR124, VIM, EFEMP2, and TBX2) and in the gray60 module (COL8A2, MATN2, KANK2, COL6A1, TRPC1, COL16A1, COL3A1, RUNX1T1, AEBP1, COL1A1, and RGS11) showed a positive correlation with maternal BMI and/or obesity, as well as with birth weight. Here, FZD4 is linked to obesity due to melanocortin 4 receptor deficiency.