In male adults, hyperinsulinemia was found to be associated with a decreased expression of Wnt signaling genes (including FZD4) in adipose tissue, while expression was increased in skeletal muscle, which might reflect a compensatory mechanism to increase muscle glucose uptake and to generate new fat cells (Karczewska-Kupczewska et al., 2016). The gene discussed is FZD4; the disease is Hyperinsulinemia.