Hypermethylation of miR-124-2 is strongly associated with advanced pathologic stage and grade of differentiation. Restoration miR-124-3p reduces migration, invasion, proliferation, metastasis; decreased cell cycle S phase; increases patient survival, drug resistance. By sponging miR-124 HOTAIR as ceRNA upregulated ST8SIA4 and promoted the proliferation and metastasis in RCC. This evidence concerns the gene HOTAIR and renal cell carcinoma.