EMT causes the development of sarcomatoid ccRCC (the most unfavorable form of cancer) due to the switched expression of E-cadherin to N-cadherin, dissociation of β-catenin from the membrane, and increased expression of SNAIL and SPARC (Conant et al., 2011). This evidence concerns the gene SNAI1 and nonpapillary renal cell carcinoma.