SOX4 and neoplasm: The tumor suppressor and anti-metastatic functions of the hypermethylated MIR-129-2 gene we discovered (Beresneva et al., 2013), are consistent with the data that miR-129-3p downregulates multiple metastasis-related genes in RCC cells, including SOX4, and also decreased phosphorylation of focal adhesion kinase and expression of MMP-2/9 (Chen et al., 2014).