In particular, IL-1β, IL-4, IFNγ, and TNFα upregulate expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin on endothelium cells, thus reinforcing the important role of inflammatory molecules in recruiting and regulating the glandular infiltrate in SS patients (19). This evidence concerns the gene IL1B and synovial sarcoma.