In order to explore adjunctive inflammatory mechanisms underlying atherosclerosis in SS, Gravani et al. analyzed the contribution of the Wingless-type (Wnt) signaling pathway (48), a key regulator of inflammation whose soluble Dickkopf WNT signaling pathway inhibitor 1 (DKK1) has been associated with atherosclerosis. The gene discussed is DKK1; the disease is atherosclerosis.