Indeed, infiltrating Th17 cells represent the major source of IL-17, a potent pro-inflammatory cytokine regulated by other cytokines highly expressed in SS glandular tissue, like IL-22 and−23, and able to interact with IL-18 to induce IL-6 and IL-8 from salivary gland cells of SS patients (18). Here, IL18 is linked to synovial sarcoma.