Of note, in SS patients, increased concentration of S100A8/A9 was identified both at glandular site, where correlated with focus score, and in the circulation, where was associated with an increased production of IL-1β, IL-6, TNFα, IFNγ, IL-10, IL-17A, and IL-22 (50). This evidence concerns the gene IL1B and synovial sarcoma.