Finally, the demonstration that the purinergic P2X7 receptor (P2X7R)-NLRP3 inflammasome complex may be involved in the pathogenesis of SS focal sialadenitis through caspase1-mediated IL-18 release highlights still unexplored mechanisms strictly linking inflammatory pathogenesis of SS glandular infiltrate and inflammatory component of arterial wall atherosclerotic damage (54). Here, IL18 is linked to synovial sarcoma.