IL-6 released from unstimulated macrophages maintained for 5 h in RPMI was significantly higher in SLE patients vs. HC (SLE-NS vs. HC: 329.0 ± 83.74 vs. 11.83 ± 0.51, p = 0.0102; SLE-S vs. HC = 29.18 ± 4.85 vs. 11.83 ± 0.51, p = 0.0021) and in patients without serositis vs. patients with serositis (SLE-NS vs. SLE-S, p = 0.014) (Figure 4A). The gene discussed is IL6; the disease is systemic lupus erythematosus.