This disintegration – a condition known as nucleolar stress and an emerging mechanism associated with cellular stress and age-related neurodegenerative diseases such AD, PD, and HD – may result in the increased stability of p53 (Hetman and Pietrzak, 2012; Parlato and Kreiner, 2013; Chan, 2014;Parlato and Liss, 2014; Parlato and Bierhoff, 2015). Here, TP53 is linked to Huntington disease.