PDX1 and neoplasm: Tumours of the squamous subtype were reported to be characterised by the presence of gene programmes and networks involved in the regulation of inflammation, hypoxia response and TGFβ signalling, among other roles, and showed upregulated expression of TP63ΔN along with frequent TP53 mutations, as well as activation of epidermal growth factor signalling.12 Pancreatic progenitor tumours were defined by transcriptional networks containing transcription factors involved in early pancreatic development (e.g. FOXA2/3, PDX1 and MNX1).