The budding phenotype also appears to be influenced by microRNA dysregulation.20 Tumour buds display reduced expression of miR‐200b and miR‐200c, which correlates inversely with the increased expression of ZEB1 and ZEB2 in PDAC cases with high-grade budding.20,28 As members of the miRNA-200 family have been shown to exert strong suppressive effects on cell transformation, proliferation, migration, invasion, tumour growth and metastasis,29–31 their marked downregulation is likely to have a crucial role in the formation of tumour budding. Here, ZEB1 is linked to neoplasm.