HNRNPK and breast cancer: Based on the role that Aurora-A plays in promoting breast cancer, we herein have investigated the cellular function(s) of hnRNPK S379 phosphorylation in MDA-MB-231 cells by establishing several stable clones in which the endogenous hnRNPK gene has been replaced by either a S379 phosphorylation-defective hnRNPK gene (S379A) or a S379 phosphorylation-mimic hnRNPK gene (S379D) (Fig. 2a).