The GluN2C subunits are expressed in brain areas such as pontine reticular formation, mediodorsal thalamus, nucleus reticularis and in astrocytes in cortical regions1,4,38 which are relevant to schizophrenia circuitry and mediate startle and PPI32,39,40, suggesting that these receptors may at least partly regulate these processes. Here, GRIN2C is linked to schizophrenia.