Pathway analysis of upregulated genes showed over-representation of cell cycle progression genes in LNK-overexpressing cells treated with IFN-γ (e.g., upregulation of MYC and CCNE2), while many genes involved in autoimmune disease were downregulated in these cells (pathways related to inflammatory bowel disease, graft versus host disease, Fig. 4a, left panel,+IFN-γ 24 h). Here, SH2B3 is linked to inflammatory bowel disease.