In three melanoma cell lines that harbored the BRAF V600E mutation (A375, M229 and M238), treatment of the cells (24 h) with either the BRAF inhibitor vemurafenib (PLX4032) or a MEK inhibitor (U0126) significantly downregulated the LNK mRNA and protein expression (Fig. 1g, h). Here, SH2B3 is linked to melanoma.