SH2B3 and neoplasm: However, forced expression of LNK enhanced the anchorage-independent clonal growth in soft agar (Fig. 2b) and generated bigger tumors in an in vivo xenograft model (Fig. 2c, d); while silencing of Lnk using CRISPR-Cas9 reduced the tumor formation of murine melanoma B16/F10 cells (Fig. 2c, d).