SH2B3 and melanoma: Compared to either normal skin tissue (Supplementary Fig. 1, RNA sequencing of 473 sun-exposed normal skin samples and 387 non-sun-exposed normal skin samples, collected from the GTEX database [https://www.gtexportal.org]) or benign nevi, LNK mRNA was significantly upregulated in the melanoma samples, particularly in advanced stages of the disease (vertical growth phase, metastatic growth phase vs primary/in situ melanoma, Fig. 1b–d) and ranked as one of the top 1% overexpressed genes in melanoma (Riker Melanoma, Oncomine database, Fig. 1b).