Individuals with elevated Aβ34/Aβ42 were not significantly older (Fig. 7b), but they exhibited significantly increased Cardiovascular Risk Factors, Aging, and Incidence of Dementia scores (CAIDE; Fig. 7c), and significantly increased CSF levels of total- and phosphorylated-tau (t-tau, p-tau; Fig. 7d, e). Here, MAPT is linked to dementia.