However, in the nucleus of human IPF fibroblasts (Fig. 9b), we detected both increase of active EP300, which inactivates HDAC1 and disrupts HDAC1-C1D interaction, and reduced levels of MIRLET7D, which compromises MiCEE-mediated epigenetic gene silencing. Here, HDAC1 is linked to idiopathic pulmonary fibrosis.