In all these models of IPF, we detected upon EP300 inhibition reduced extracellular matrix protein deposition (Fig. 7b, c; Supplementary Fig. 8c, Fig. 8a and 8d), reduced levels of fibrotic markers, such as FN1, COL1A1, and ACTA2 (Fig. 7d; Supplementary Fig. 8d and Fig. 8f), and reduced cell migration and proliferation (Fig. 8b, 8c and 8e). This evidence concerns the gene EP300 and idiopathic pulmonary fibrosis.