LOF of MIRLET7D (by antagomiR probes)32, EXOSC10 (by short hairpin RNA construct, shRNA)25, and EZH2 (by small-molecule inhibitor, UNC-1999)35 in Ctrl human primary lung fibroblasts increased cell migration (Fig. 4a, b and Supplementary Fig. 3a, b), cell proliferation (Fig. 4c), and levels of fibrotic markers (Fig. 4d) to similar levels as in IPF fibroblasts, thereby demonstrating the requirement of the MiCEE complex for appropriate lung fibroblast functions. Here, EZH2 is linked to idiopathic pulmonary fibrosis.