This observation was confirmed by WB of protein extracts from IPF fibroblasts after MIRLET7D-GOF (Supplementary Fig. 6a, right), as well as by detection of inactive EP300 (inaEP300) by ChIP of MIRLET7D targets using antibodies specific for phosphorylated EP300 at serine 8942 (Supplementary Fig. 6c, right). Here, EP300 is linked to idiopathic pulmonary fibrosis.