Therefore, we explore the effects of other mechanisms on cell invasion and migration, we hypothesize that QGS can inhibits the cell mobility of ESCC by inhibiting the Gas6 to regulating the Gas6/AXL signaling pathway, which leads to the decrease of PI3K, AKT, NF-κB, matrix metalloproteinase-2 (MMP2) and matrix metalloproteinase-9 (MMP9) signals. Here, MMP2 is linked to esophageal squamous cell carcinoma.