SNCA and multiple system atrophy: This can be accounted for by the fact that despite the slightly lower α-synuclein expression in astrocytes from the latter line, the sequence of α-synuclein in MSA brain homogenate is wild-type, which is the same as the α-synuclein expressed in the Tg(SNCA+/+)Nbm astrocytes on the mouse Snca knockout background.