PGAP6 and multiple system atrophy: The use of P0 mouse pups allows for rapid completion of experimental cohorts and building on previous studies in which neonatal mice were injected intracerebroventricularly with recombinant adeno-associated virus [8], which allowed for widespread transduction of the neonatal mouse brain, we conducted a comparison of pathology induced by MSA brain lysates in hemizygous M83+/− mice that express A53T human αS, hemizygous M20+/− mice that express human wild type (WT) αS, and non-transgenic (nTg) mice with the same genetic background.