Interestingly, a famous brain-enriched circRNA, CDR1as, which is known as a sponge for miR-7 regulating various diseases, such as cancer [22] and neurodegenerative diseases [23], showed increased expression with age (Fig. 2c), implying that CDR1as may be involved in aging of the brain. Here, LINC00632 is linked to neurodegenerative disease.