In our previous study of 35 patients with A-DLBCL, we defined A-DLBCL based on morphology and recognized the distinctiveness of this neoplasm from ordinary DLBCLs in terms of genetic alterations and biologic features, which contained a high incidence of p53 positivity and MYC/BCL2 double-expressor and a high frequency of TP53 mutations and concurrent MYC and BCL2 and/or BCL6 abnormalities [6]. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.