Furthermore, our data revealed the role of TGIF1 in regulating TGFβ-induced hyaluronan synthase 2 (HAS2) activity, which has a profound effect on tumor-associated macrophage (TAM) polarization; moreover, TGIF1 exhibits an antitumor immunity potential through the suppression of PD-L1 expression. The gene discussed is HAS2; the disease is neoplasm.