In particular, polarization of macrophages to the M2-like activation state increases the production of IL-4 and M-CSF as well as upregulation of several chemokines including CCL1, CCL24, and CCL17; furthermore, M2 macrophages play a crucial role in mediating tissue remodeling, immune regulation, and tumor promotion [54]. The gene discussed is CCL1; the disease is neoplasm.