Previous studies have shown that several derivatives of the high affinity sigma-2 receptor agonist PB28 (1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine), have the ability to inhibit the growth of pancreatic cancer [20, 25] and the neuroblastoma SK-N-SH cell line [19]. The gene discussed is TMEM97; the disease is familial pancreatic carcinoma.