AP2S1 and pancreatic neoplasm: Our results reveals that the effect of PB221-reduced migration and invasion (Fig. 4b and c) and the PB221-induced apoptotic cell death (Fig. 4d) on ALTS1C1 could be reduced by the lipid antioxidant α-tocopherol, but not by the hydrophilic N-acetylcysteine, as previously verified for PB28 derivatives [20] and by differently structured sigma-2 ligands, such as thiosemicarbazones in pancreatic tumor cells [29].