Despite SF3B1 being associated with good prognosis and low metastatic potential (class 1 tumour), this subset of this tumour of the eye shows an intermediate risk of late onset metastasis, as confirmed by a large uveal melanoma disomy 3 cohort study recently conducted by Yavuzyigitoglu et al. using whole-exome sequencing analysis [57]. Here, SF3B1 is linked to neoplasm.