ATM and Ataxia-telangiectasia: Aneuploidization of the brain in ataxia telangiectasia is a result of mutations in ATM (ataxia telangiectasia mutated) gene, which is involved in numerous molecular and cellular pathways (i.e., apoptosis, cell cycle, cellular senescence, cellular responses to stress, DNA damage response, DNA repair, etc.)[178,207,208,209].