Placebo-controlled studies suggest that the sub-anesthetic infusion of rac-K lowers suicidal ideation in patients suffering from bipolar depression to a greater degree than midazolam (used to address functional unblinding due to dissociative effects associated with verum administration), and demonstrated memory improvement and pre- to post-infusion decrease in serum brain-derived neurotrophic factor (BDNF) as promising biomarkers [3]. The gene discussed is BDNF; the disease is bipolar disorder.