This material was reported to have anti-oxidative activity by increasing the levels of SOD, CAT, GST and decreasing TBARS level in liver [29] and anti-obesity activity in HFD-induced mice or anti-obesity activity for inducing apoptosis in 3T3-L1 adipocytes, but few studies have examined these effects [30]. Here, SOD1 is linked to obesity due to melanocortin 4 receptor deficiency.