PRKCA and colorectal carcinoma: Only after incubation with the PKCα activators PMA and PEP005, including at concentrations as low as 1 nM for PMA and 10 nM for PEP005, PKCα-overexpressing DLD-1 cells showed morphological changes, stopped growing, and died, clearly demonstrating the anti-tumor effect of PKCα activity in CRC cells.