PTGS2 and lung cancer: Research aimed at identifying safer cancer treatments has suggested that non-steroidal anti-inflammatory drugs (NSAIDs), such as acetylsalicylic acid (aspirin), sulindac, and indomethacin have chemopreventive and antitumor effects against several types of malignancy, including colorectal, ovarian, breast, and lung cancer [6,7,8,9]; however, continuous NSAID use is strongly associated with gastric ulcers (induced by non-selective NSAIDs) or cardiovascular effects (caused by cyclooxygenase-2 selective inhibitors) [10,11].