The Multi-Ethnic Study of Atherosclerosis (MESA) cohort study in which 3002 men and women, aged 59 ± 9.7 years, without cardiovascular antecedents were followed up for 9.0 years found that higher PTH serum concentrations were associated with a greater risk of hypertension, even after adjusting for potential confounders (HR = 1.27, 95% CI = 1.01–1.59) [39]. The gene discussed is PTH; the disease is hypertensive disorder.