Different common genetic alterations (gene mutation, gene amplifications, copy-number gains, gene translocations and aberrant gene methylation) have been identified in WDTC (PTC and FTC) and, in PDTC, UTC/ATC, being the most frequent: point mutations affecting oncogenes (BRAF, RAS, TP53, and CTNNB1), rearrangements affecting RET-PTC and NTRK genes. The gene discussed is RET; the disease is thyroid cancer, nonmedullary, 2.