In addition, miR-1 expression was found to be decreased gradually in the DM, CAD + DM and HF + DM groups Furthermore miR-1 was negatively correlated with the NT-proBNP and galectin-3 levels in the CAD + DM and HF + DM groups and it especially showed the strongest correlation in the HF + DM group. The gene discussed is NPPB; the disease is hydrops fetalis.