ADORA2A and Parkinson disease: Notably, A2A-D2 heteromers emerging from the interaction of the adenosine A2A receptor and the dopamine D2 receptor in the striatal neuron plasma membrane opened up new comprehension of the Parkinson’s disease (PD) pathophysiology and of the adverse anti-Parkinson’s drug reaction [8,19,20,21,22,23,24,25,26,27].