Curcumin inhibits Wnt/β catenin pathway by suppressing c-myc expression, induce caspase 3 mediated cleavage of β-catenin, E-cadherin, and APC, which were linked to apoptosis and G2/M phase arrest in HCT-116 colon cancer cells [163,164]. This evidence concerns the gene APC and colonic neoplasm.