MAPK8 and colorectal carcinoma: Curcumin also displays the ability to signal switch the MEK/ERK proliferative signaling to p38 MAPK/JNK1 pro-apoptotic pathway leading to phosphorylation of p53, transactivate BAX and Bcl-2 binding component 3 (PUMA) genes, promoting cell death in human CRC [310].