Study done by Dasiram et al. [321] however, demonstrated curcumin able to induce apoptosis in COLO-320DM colon cancer cells (Dukes’ type C stage) carrying mutated TP53 and arresting the COLO-320DM human colon adenocarcinoma at G1 and S phases. The gene discussed is TP53; the disease is colon adenocarcinoma.