Increased level of GRP78, which was observed in colon cancer cell [397,398,399] functions as chaperone may dissociate from its conformational binding state of the transmembrane receptor protein kinase RNA like endoplasmic reticulum kinase (PERK), IRE1 and activating transcription factor 6 (ATF6). Here, ATF6 is linked to malignant colon neoplasm.