Activation of the AKT leads to inhibition of Bcl-2-associated death promoter (BAD) and Bax pro-apoptotic protein [187,190,195], suppression of p53-mediated apoptosis via Mdm2 phosphorylation, increased transcription of anti-apoptotic and pro-survival genes via NF-κB transcription factor [187,196], and induce activation of mTOR which is a group of protein associated with cancer metastasis [190]. Here, TP53 is linked to cancer.