AKT1 and colorectal carcinoma: Redox modifications of protein cysteine residues in CRC development may involve with signaling pathway and transcriptional factors modulators [353] such as Sp [342], NF-κB [354,355,356], p53 [357,358,359,360], HIF-1α [361,362], and Nrf2 transcription factor [342,363,364,365], c-Myc [351], MAPK cascade [366,367,368], PI3K/AKT [369,370,371], and janus kinases/signal transducer and activator of transcription proteins (JAK/STAT) signaling pathway [358,372].