In addition, curcumin was found to suppress growth and induce apoptosis of colon cancer cells via inhibition of hepatocyte growth factor receptor (c-MET), specificity protein (Sp) transcription factor such as Sp1, Sp3, Sp4, and Sp-regulated genes including Survivin, cyclin D1, Bcl-2, and NF-κB (p65 and p50) [153]. This evidence concerns the gene CCND1 and malignant colon neoplasm.