Suppression of apoptosis and continuous inhibition of JNK activation in CRC occurs as the results of the constitutive activation of NF-κB that targets the anti-apoptotic genes via the p65/Re1A domain to X-linked inhibitor of apoptosis (XIAP), A20 and Bcl-xL [70]. The gene discussed is MAPK8; the disease is colorectal carcinoma.