The role of Cyclin D1 includes the cell cycle transition from G1 to S phase [207], as a transcription factor [208,209,210], mitochondria biogenesis [211,212,213,214,215,216] and genomic instability [217], which may directly or indirectly involve in disruption of apoptosis [218] in CRC. This evidence concerns the gene CCND1 and colorectal carcinoma.