Degenerative diseases such as Alzheimer’s disease (AD), prion-associated spongiform encephalopathies, type II diabetes, transthyretin amyloidosis, and Parkinson’s disease are associated with accumulation of insoluble misfolded protein aggregates, such as amyloid and tau aggregates, in afflicted tissues [77,78,79,80]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.