EC-rich cocoa intake increased levels of Sirt 1, PGC-1α, TFAM, and complex I and V in skeletal muscle samples obtained by biopsy from patients with type 2 diabetes and heart failure [90], and EC-rich dark chocolate significantly increased AMPA and PGC-1α in samples from normal sedentary subjects [91]. This evidence concerns the gene PPARGC1A and type 2 diabetes mellitus.