Various small-molecule inhibitors of the Colony stimulating factor 1 receptor (CSF-1R) or C-C motif chemokine receptor (CCR)-2, which mediate the recruitment of TAMs to the tumor, or inhibitors of TAM-derived pro-stemness factors have shown anti-stemness and anti-tumor efficacies in preclinical studies [44,47,48]. This evidence concerns the gene CSF1R and neoplasm.