Similarly, in a mouse model of PDAC, the number of bone marrow-derived MSCs significantly increased following gemcitabine treatment in the tumor stroma, and the gemcitabine-educated MSCs have a positive regulatory effect on CSCs through the STAT-3–CXCL-10–CXCR-3 paracrine signaling axis [82]. The gene discussed is STAT3; the disease is neoplasm.