In boys, higher SSB intake was associated with higher C-peptide (Q4 vs. Q1 of SSB intake: 0.72 [95% confidence interval (CI): 0.16, 1.27] ng/mL; P-trend across quartiles = 0.04), C peptide insulin resistance (CP-IR) (Q4 vs. Q1 of SSB intake: 0.17 [95% CI: 0.04, 0.30] ng/mL; P-trend across quartiles = 0.03), and leptin (Q4 vs. Q1 of SSB intake: 3.78 [95% CI: 0.49, 7.08] ng/mL; P-trend across quartiles = 0.02). The gene discussed is CP; the disease is Insulin resistance.