In addition, high-dose radiation of 10 Gy or higher induces the release of damage-associated molecule patterns (DAMPs), such as high mobility group box 1 (HMGB1), by apoptotic and necrotic cells and induces the recruitment of CD11b+ myeloid cells in the TME and reprogramming macrophages towards the tumor-promoting M2-phenotype [52,53,54]. The gene discussed is HMGB1; the disease is neoplasm.