Monocytes co-cultured with CAFs from pancreatic ductal adenocarcinoma have been shown to present with increased surface expression of specific M2-markers, e.g., CD163, CD200R, and CD206 surface receptors and up-regulation of ARG1, IL10, and TGFB1 genes [28]. Here, ARG1 is linked to pancreatic ductal adenocarcinoma.