In addition, lactoferrin, an abundant neutrophil-derived protein released upon activation at sites of inflammation, possesses a greater iron-binding affinity than transferrin and has a broad mycobacteriostatic activity, by sequestering iron; moreover, congenital lactoferrin deficiency leads to recurring infection [78,79]. This evidence concerns the gene LTF and hyperinsulinemic hypoglycemia, familial, 4.