While CD28-based anti-CD19 CAR T cells have shown potent anti-tumor activity, they generally persist for only a limited time [21,24,101] and have therefore been suggested to constitute a potent bridge-to-transplant approach, whereby remission is induced via CAR T cell therapy followed by allogeneic hematopoietic stem cell transplantation (HSCT) [101,102]. The gene discussed is CD28; the disease is neoplasm.