ANGPT2 and familial pancreatic carcinoma: Ang2 was a direct target of miR-145, as miR-145 overexpression downregulated Ang2 in the BxPC3, MiaPaCa-2, and Panc-1 cells, suppressing cell invasion and colony formation, and inhibiting the growth of pancreatic cancer xenografts and angiogenesis in vivo [78].