Silencing of Ang2, β1 integrin, or α5-integrin inhibited endothelial monolayer destabilization by thrombin, interleukin (IL)-1β, or LPS in an endotoxemia model, further highlighting the significance of β1 integrin in Ang2-induced endothelial cell functions [126]. This evidence concerns the gene ANGPT2 and serum lipopolysaccharide activity.