CASP3 and leukemia: Dörrie et al. found RES-induced apoptosis by depolarizing mitochondrial membranes and activating caspase-3 in human pro-B acute lymphoblastic leukemia cell lines SD, RS4-11, MV4-11, human pre-b leukemia cell lines REH, Nalm-6, and human T-cell leukemia cell lines Jurkat and CEM [40].