Voluntary activity had no impact on the HSD-related body weight increase (CD-active (A): 39.2 ± 4.1 g, HSD-A: 43.4 ± 2.8 g, p = 0.045; HSD vs. HSD-A p = 0.176), but prevented hyperglycemia in the active HSD-group (CD-A: 8.0 ± 0.5 mmol/L, HSD-A: 8.3 ± 0.3 mmol/L, p = 0.373; HSD vs. HSD-A p < 0.001). This evidence concerns the gene CHST3 and Hyperglycemia.