For example, the androgen downregulation of complement 3, Cxcl9, moesin, IL-1β, and TLR2 genes may interfere with the early stages of SS disease development and the triggering of an adaptive immune response in the lacrimal gland.30,45, , , , –50 However, if these five genes are important for the androgen-induced downregulation of lacrimal gland inflammation in female MRL/lpr mice, why are these same genes upregulated by androgen treatment in lacrimal tissues of female NOD mice? Here, CXCL9 is linked to synovial sarcoma.