EGF and skin neoplasm: Since JB6 P+ cells only express functional β2-ARs [13], which is the same for the human skin keratinocytes [21], and carvedilol-mediated inhibition of EGF-induced transformation of JB6 P+ cells mimic UV-induced skin cancer in SKH-1 mice [14], SKH-1 Adrb2 knockout mice were used to study the role of the β2-AR in UV-induced skin damage.