NFE2L2 and lung adenocarcinoma: Interestingly, the incidence of CDO1 promoter methylation was significantly higher and its mRNA expression significantly lower in KEAP1 mutant lung adenocarcinoma compared to wild-type (Figure 3A,B), and NRF2 activity high lung adenocarcinoma compared to NRF2 low (Figure 3—figure supplement 1C), suggesting that CDO1 expression confers a selective disadvantage in the context of NRF2 accumulation.