To investigate the NRF2-dependent regulation of CDO1 protein in NSCLC, we generated a doxycycline-inducible lentiviral expression system to reintroduce GFP, CDO1WT or a catalytically inactive CDO1 mutant (Y157F, Ye et al., 2007) at single copy into the panel of NRF2LOW and NRF2HIGH NSCLC cell lines (Figure 3D, Figure 3—figure supplement 2). This evidence concerns the gene CDO1 and non-small cell lung carcinoma.