NFE2L2 and non-small cell lung carcinoma: To investigate the NRF2-dependent regulation of CDO1 protein in NSCLC, we generated a doxycycline-inducible lentiviral expression system to reintroduce GFP, CDO1WT or a catalytically inactive CDO1 mutant (Y157F, Ye et al., 2007) at single copy into the panel of NRF2LOW and NRF2HIGH NSCLC cell lines (Figure 3D, Figure 3—figure supplement 2).