TOP2B and neoplasm: To verify the hypothesis, we used DEX, which induces Top2β depletion and antagonizes DOX‐induced cardiotoxicity by preventing DOX‐induced DNA damage, whilst not decreasing the anti‐tumour efficacy at the same time.33 In our findings, DNA damage signal γ‐H2A.X is more significantly reduced with treatment of DEX in the day 60 cells than in the day 30 cells, which supports our hypothesis (Figure 5D,E).